Iowa Translational Vascular Physiology Lab

Lab Mission Statement

The overall mission of the Iowa Translational Vascular Physiology Lab (TVPL) in the Department of Health and Human Physiology is to determine the mechanisms that contribute to the development of vascular dysfunction (e.g.,endothelial dysfunction, arterial stiffness, cerebrovascular dysfunction) and cognitive decline in humans at high risk for cardiovascular diseases (CVD) including persons who are aged, or have obesity, hypertension, prediabetes, chronic obstructive pulmonary disease (COPD), chronic anxiety or pregnant women at risk for preeclampsia.

Pierce Lab Photo, UIowa, 2017
Lab members from left to right (Spring 2017):  Seth Holwerda, PhD; Gary Pierce, PhD; Rumbi Majee; Alli O'Deen, BA; Leah Reierson; Rachel Luehrs, MS; Janie Myers, BS; Amy Stroud, RN, MSN; Nealy Wooldridge, BS; Nick Jensen; Lauren Points, PhD; Lyndsey DuBose, MS (Missing: Adam Fitzsimmons ; Deb Brandt, PhD, RN; Melissa Rader)
  • We conduct acute experimental and short-term intervention studies testing the efficacy of pharmacological and lifestyle interventions on vascular structure/ function, autonomic function, cerebrovascular and cognitive funciton in humans at high risk for developing CVD.
  • Our lab uses an integrative experimental approach, including non-invasive and semi-invasive approaches to assess vascular endothelial function of peripheral arteries, stiffness and pulsatile hemodynamics of the large central elastic arteries (e.g., aorta, carotids), and cerebrovascualar function (blood flow/reactivity), blood pressure variability and muscle sympathetic nerve activity in human subjects.
  • We also study cells/tissues (endothelial cells, mononuclear cells, serum/plasma, arterioles from human adipose biopsies) isolated from subjects and perform complimentary in vitro experiments in endothelial cells to provide insight into the cellular/molecular mechanisms that contribute to baseline vascular dysfunction and in response to the pharmacological and lifestyle interventions.