Recent Publications


Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Am J Physiol Regul Integr Comp Physiol. 2018 Jan 24. doi: 10.1152/ajpregu.00435.2017. [Epub ahead of print] Read Article


Lane-Cordova AD, Kalil GZ, Wagner CJ, Sindler AL, Fiedorowicz JG, Ajibewa T, Haynes WG, Pierce GL. Hemoglobin A1c and C-reactive protein are independently associated with blunted nocturnal blood pressure dipping in obesity-related prediabetes. Hypertens Res. 2017 Oct 26. doi: 10.1038/hr.2017.82. Read Article

Pierce GL. Aortic Stiffness in Aging and Hypertension: Prevention and Treatment with Habitual Aerobic Exercise. Curr Hypertens Rep. 2017 Oct 18;19(11):90. doi: 10.1007/s11906-017-0788-0. Review. Read Article

Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ. Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function. Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H890-H895. doi: 10.1152/ajpheart.00416.2017. Epub 2017 Sep 29. Read Article

Pierce GL. Mechanisms and Subclinical Consequences of Aortic Stiffness. Hypertension. 2017 Nov;70(5):848-853. doi: 10.1161/HYPERTENSIONAHA.117.08933. Epub 2017 Sep 5. Review. Read Article

Casey DP, Ueda K, Wegman-Points L, Pierce GL. Muscle contraction induced arterial shear stress increases endothelial nitric oxide synthase phosphorylation in humans. Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H854-H859. doi: 10.1152/ajpheart.00282.2017. Epub 2017 Aug 11. Read Article

DuBose LE, Voss MW, Weng TB, Kent JD, Dubishar KM, Lane-Cordova AD, Sigurdsson G, Schmid P, Barlow PB, Pierce GL. Carotid β-stiffness Index is Associated with Slower Processing Speed but not Working Memory or White Matter Integrity in Healthy Middle-Aged/Older Adults. J Appl Physiol 2017;122;868-876. Read Article

Pierce GL, Kalil GZ, Ajibewa T, Holwerda SW, Persons J, Moser DJ, Fiedorowicz JG. Anxiety independently contributes to elevated inflammation in humans with obesity. Obesity 2017;25:286-289. Read Article


Pierce GL, Pajaniappan M, DiPietro A, Darracott-Woei-A-Sack K, Kapuku GK.  Abnormal central pulsatile hemodynamics in adolescents with obesity: higher aortic forward pressure wave amplitude is independently associated with greater left ventricular mass.  Hypertension 2016;68:1200-1207. Read Article

Lane-Cordova AD, Witmer JR, Dubishar K, DuBose LE, Chenard CA, Siefers KJ, Myers JE, Points LJ, Pierce GL. High trans but not saturated fat beverage causes an acute reduction in postprandial vascular endothelial function but not arterial stiffness in humans.Vasc Med. 2016;21:429-436.  Read Article

Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW Jr, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM.  Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. Hypertension 2016;67:674-680. Read Article

Pierce GL, Harris SA, Seals DR, Casey DP, Barlow P, Stauss HM. Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of aging and habitual endurance exercise. J Hum Hypertens 2016;30:513-520. Read Article

Kalil GZ, Recober A, Hoang-Tienor A, Zimmerman MB, Haynes WG, Pierce GL. Higher augmentation index is associated with tension-type headache and migraine in middle-aged/older humans with obesity. Obesity 2016;24:865-70. Read Article


Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL.  Vasopressin: the missing link for preeclampsia?Am J Physiol Regul Integr Comp Physiol. 2015;309:R1062-4. Read Article

Weng TB, Pierce GL, Darling WG, Voss MW.  Differential effects of acute exercise on distinct aspects of executive function. Med Sci Sports Exerc. 2015;47(7):1460-9. Read Article

Montero D, Pierce GL, Stehouwer CD, Padilla J, Thijssen DH. The impact of age on vascular smooth muscle function in humans. J Hypertens 2015 Mar;33(3):445-53. Read Article


Franklin SS, Pierce GL. Cardiorespiratory fitness and the attenuation of age-related rise in blood pressure: an important role for effective primordial prevention. J Amer Coll Cardiol 2014;64:1254-1256. Read Article

Walker AE, Kaplon RE, Pierce GL, Nowlan MJ, Seals DR. Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: Possible role of nuclear factor-κB. Clin Sci 2014;127:645-654. Read Article


Pierce GL. Oral BH4: a novel remedy for age-related skin microvascular dysfunction during hyperthermia or fool’s elixir? J Appl Physiol 2013;115:951-3. Read Article

Pierce GL. Targeting vascular endothelial insulin resistance in type 2 diabetes mellitus: is protein kinase C beta the ‘bullseye’ for reducing vascular risk in diabetes? Circulation 2013; 127:16-18. Read Article

Chalouhi N, Points L, Pierce GL, Ballas Z, Jabbour P, Hasan D. Localized increase of chemokines in the lumen of human cerebral aneurysms. Stroke 2013;44:2594-97. Read Article

Pierce GL, Casey DP, Fiedorowicz JG, Seals DR, Curry TB, Barnes JN, Wilson D, Stauss HM. Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences. Am J Physiol Heart Circ Physiol 2013;305:H135-H142. Read Article

Pierce GL, Zhu H, Darracott K, Edet I, Bhagatwala J, Huang Y, Dong Y.  Arterial stiffness and pulse pressure amplification in overweight/obese African-American adolescents: relation with higher systolic and pulse pressure. Am J Hypertens 2013;26:20-26. Read Article

DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonksi KL, Kaplon RE, Seals DR. Regular aerobic exercise protects against impaired fasting glucose-associated vascular endothelial dysfunction with aging. Clin Sci 2013; 124:325-331. Read Article